diff --git a/Lib/uuid.py b/Lib/uuid.py
index 8fe2479f3f2..e863b631877 100644
--- a/Lib/uuid.py
+++ b/Lib/uuid.py
@@ -371,7 +371,12 @@ def _get_command_stdout(command, *args):
         # for are actually localized, but in theory some system could do so.)
         env = dict(os.environ)
         env['LC_ALL'] = 'C'
-        proc = subprocess.Popen((executable,) + args,
+        # Empty strings will be quoted by popen so we should just ommit it
+        if args != ('',):
+            command = (executable, *args)
+        else:
+            command = (executable,)
+        proc = subprocess.Popen(command,
                                 stdout=subprocess.PIPE,
                                 stderr=subprocess.DEVNULL,
                                 env=env)
@@ -511,7 +516,7 @@ def _ifconfig_getnode():
         mac = _find_mac_near_keyword('ifconfig', args, keywords, lambda i: i+1)
         if mac:
             return mac
-        return None
+    return None
 
 def _ip_getnode():
     """Get the hardware address on Unix by running ip."""
diff --git a/Misc/NEWS.d/next/Core and Builtins/2022-10-19-01-01-08.gh-issue-98415.ZS2eWh.rst b/Misc/NEWS.d/next/Core and Builtins/2022-10-19-01-01-08.gh-issue-98415.ZS2eWh.rst
new file mode 100644
index 00000000000..af2db1f9965
--- /dev/null
+++ b/Misc/NEWS.d/next/Core and Builtins/2022-10-19-01-01-08.gh-issue-98415.ZS2eWh.rst	
@@ -0,0 +1 @@
+Fix detection of MAC addresses for :mod:`uuid` on certain OSs. Patch by Chaim Sanders