diff --git a/Lib/test/test_syntax.py b/Lib/test/test_syntax.py
index 02372baf827..5926b69c93b 100644
--- a/Lib/test/test_syntax.py
+++ b/Lib/test/test_syntax.py
@@ -67,6 +67,10 @@ SyntaxError: can't assign to literal
 Traceback (most recent call last):
 SyntaxError: can't assign to literal
 
+>>> b"" = 1
+Traceback (most recent call last):
+SyntaxError: can't assign to literal
+
 >>> `1` = 1
 Traceback (most recent call last):
 SyntaxError: invalid syntax
diff --git a/Misc/NEWS b/Misc/NEWS
index 9a12912e8aa..bfa8f83b327 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -716,6 +716,9 @@ Core and Builtins
 
 - Add sys.flags attribute for the new -q command-line option.
 
+- Issue #11506: Trying to assign to a bytes literal should result in a
+  SyntaxError.
+
 Library
 -------
 
diff --git a/Python/ast.c b/Python/ast.c
index e62a2156b71..5b12da80f2c 100644
--- a/Python/ast.c
+++ b/Python/ast.c
@@ -483,6 +483,7 @@ set_context(struct compiling *c, expr_ty e, expr_context_ty ctx, const node *n)
         case Set_kind:
         case Num_kind:
         case Str_kind:
+        case Bytes_kind:
             expr_name = "literal";
             break;
         case Ellipsis_kind: