diff --git a/Misc/NEWS b/Misc/NEWS
index 3da2567562b..619feb2e35c 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -298,6 +298,9 @@ Tests
 Build
 -----
 
+- Add workaround for VS 2010 nmake clean issue. VS 2010 doesn't set up PATH
+  for nmake.exe correctly.
+
 - Issue #19550: Implement Windows installer changes of PEP 453 (ensurepip).
 
 - Issue #19520: Fix compiler warning in the _sha3 module on 32bit Windows.
diff --git a/PC/python3.mak b/PC/python3.mak
index 8f9d46840b8..fb8e7aac097 100644
--- a/PC/python3.mak
+++ b/PC/python3.mak
@@ -5,6 +5,10 @@ $(OutDir)python34stub.lib:	python34stub.def
 	lib /def:python34stub.def /out:$(OutDir)python34stub.lib /MACHINE:$(MACHINE)
 
 clean:
-	del $(OutDir)python3.dll $(OutDir)python3.lib $(OutDir)python34stub.lib $(OutDir)python3.exp $(OutDir)python34stub.exp
+	IF EXIST $(OutDir)python3.dll del $(OutDir)python3.dll
+	IF EXIST $(OutDir)python3.lib del $(OutDir)python3.lib
+	IF EXIST $(OutDir)python34stub.lib del $(OutDir)python34stub.lib
+	IF EXIST $(OutDir)python3.exp del $(OutDir)python3.exp
+	IF EXIST $(OutDir)python34stub.exp del $(OutDir)python34stub.exp
 
 rebuild: clean $(OutDir)python3.dll
diff --git a/PCbuild/python3dll.vcxproj b/PCbuild/python3dll.vcxproj
index b3459b5fec1..bc8ff31ca22 100644
--- a/PCbuild/python3dll.vcxproj
+++ b/PCbuild/python3dll.vcxproj
@@ -99,7 +99,7 @@ nmake /f python3.mak MACHINE=x86 OutDir=$(OutDir)</NMakeBuildCommandLine>
     <NMakeReBuildCommandLine Condition="'$(Configuration)|$(Platform)'=='Release|Win32'">cd $(ProjectDir)\..\PC
 nmake /f python3.mak MACHINE=x86 OutDir=$(OutDir) rebuild</NMakeReBuildCommandLine>
     <NMakeCleanCommandLine Condition="'$(Configuration)|$(Platform)'=='Release|Win32'">cd $(ProjectDir)\..\PC
-nmake /f python3.mak MACHINE=x86 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
+"$(VSInstallDir)\VC\bin\nmake.exe" /f python3.mak MACHINE=x86 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
     <NMakeOutput Condition="'$(Configuration)|$(Platform)'=='Release|Win32'">$(OutDir)python3.dll</NMakeOutput>
     <NMakePreprocessorDefinitions Condition="'$(Configuration)|$(Platform)'=='Release|Win32'">$(NMakePreprocessorDefinitions)</NMakePreprocessorDefinitions>
     <NMakeIncludeSearchPath Condition="'$(Configuration)|$(Platform)'=='Release|Win32'">$(NMakeIncludeSearchPath)</NMakeIncludeSearchPath>
@@ -111,7 +111,7 @@ nmake /f python3.mak MACHINE=x64 OutDir=$(OutDir)</NMakeBuildCommandLine>
     <NMakeReBuildCommandLine Condition="'$(Configuration)|$(Platform)'=='Release|x64'">cd $(ProjectDir)\..\PC
 nmake /f python3.mak MACHINE=x64 OutDir=$(OutDir) rebuild</NMakeReBuildCommandLine>
     <NMakeCleanCommandLine Condition="'$(Configuration)|$(Platform)'=='Release|x64'">cd $(ProjectDir)\..\PC
-nmake /f python3.mak MACHINE=x64 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
+"$(VSInstallDir)\VC\bin\nmake.exe" /f python3.mak MACHINE=x64 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
     <NMakeOutput Condition="'$(Configuration)|$(Platform)'=='Release|x64'">$(OutDir)python3.dll</NMakeOutput>
     <NMakePreprocessorDefinitions Condition="'$(Configuration)|$(Platform)'=='Release|x64'">$(NMakePreprocessorDefinitions)</NMakePreprocessorDefinitions>
     <NMakeIncludeSearchPath Condition="'$(Configuration)|$(Platform)'=='Release|x64'">$(NMakeIncludeSearchPath)</NMakeIncludeSearchPath>
@@ -123,7 +123,7 @@ nmake /f python3.mak MACHINE=x86 OutDir=$(OutDir)</NMakeBuildCommandLine>
     <NMakeReBuildCommandLine Condition="'$(Configuration)|$(Platform)'=='PGInstrument|Win32'">cd $(ProjectDir)\..\PC
 nmake /f python3.mak MACHINE=x86 OutDir=$(OutDir) rebuild</NMakeReBuildCommandLine>
     <NMakeCleanCommandLine Condition="'$(Configuration)|$(Platform)'=='PGInstrument|Win32'">cd $(ProjectDir)\..\PC
-nmake /f python3.mak MACHINE=x86 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
+"$(VSInstallDir)\VC\bin\nmake.exe" /f python3.mak MACHINE=x86 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
     <NMakeOutput Condition="'$(Configuration)|$(Platform)'=='PGInstrument|Win32'">$(OutDir)python3.dll</NMakeOutput>
     <NMakePreprocessorDefinitions Condition="'$(Configuration)|$(Platform)'=='PGInstrument|Win32'">$(NMakePreprocessorDefinitions)</NMakePreprocessorDefinitions>
     <NMakeIncludeSearchPath Condition="'$(Configuration)|$(Platform)'=='PGInstrument|Win32'">$(NMakeIncludeSearchPath)</NMakeIncludeSearchPath>
@@ -135,7 +135,7 @@ nmake /f python3.mak MACHINE=x64 OutDir=$(OutDir)</NMakeBuildCommandLine>
     <NMakeReBuildCommandLine Condition="'$(Configuration)|$(Platform)'=='PGInstrument|x64'">cd $(ProjectDir)\..\PC
 nmake /f python3.mak MACHINE=x64 OutDir=$(OutDir) rebuild</NMakeReBuildCommandLine>
     <NMakeCleanCommandLine Condition="'$(Configuration)|$(Platform)'=='PGInstrument|x64'">cd $(ProjectDir)\..\PC
-nmake /f python3.mak MACHINE=x64 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
+"$(VSInstallDir)\VC\bin\nmake.exe" /f python3.mak MACHINE=x64 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
     <NMakeOutput Condition="'$(Configuration)|$(Platform)'=='PGInstrument|x64'">$(OutDir)python3.dll</NMakeOutput>
     <NMakePreprocessorDefinitions Condition="'$(Configuration)|$(Platform)'=='PGInstrument|x64'">$(NMakePreprocessorDefinitions)</NMakePreprocessorDefinitions>
     <NMakeIncludeSearchPath Condition="'$(Configuration)|$(Platform)'=='PGInstrument|x64'">$(NMakeIncludeSearchPath)</NMakeIncludeSearchPath>
@@ -147,7 +147,7 @@ nmake /f python3.mak MACHINE=x86 OutDir=$(OutDir)</NMakeBuildCommandLine>
     <NMakeReBuildCommandLine Condition="'$(Configuration)|$(Platform)'=='PGUpdate|Win32'">cd $(ProjectDir)\..\PC
 nmake /f python3.mak MACHINE=x86 OutDir=$(OutDir) rebuild</NMakeReBuildCommandLine>
     <NMakeCleanCommandLine Condition="'$(Configuration)|$(Platform)'=='PGUpdate|Win32'">cd $(ProjectDir)\..\PC
-nmake /f python3.mak MACHINE=x86 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
+"$(VSInstallDir)\VC\bin\nmake.exe" /f python3.mak MACHINE=x86 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
     <NMakeOutput Condition="'$(Configuration)|$(Platform)'=='PGUpdate|Win32'">$(OutDir)python3.dll</NMakeOutput>
     <NMakePreprocessorDefinitions Condition="'$(Configuration)|$(Platform)'=='PGUpdate|Win32'">$(NMakePreprocessorDefinitions)</NMakePreprocessorDefinitions>
     <NMakeIncludeSearchPath Condition="'$(Configuration)|$(Platform)'=='PGUpdate|Win32'">$(NMakeIncludeSearchPath)</NMakeIncludeSearchPath>
@@ -159,7 +159,7 @@ nmake /f python3.mak MACHINE=x64 OutDir=$(OutDir)</NMakeBuildCommandLine>
     <NMakeReBuildCommandLine Condition="'$(Configuration)|$(Platform)'=='PGUpdate|x64'">cd $(ProjectDir)\..\PC
 nmake /f python3.mak MACHINE=x64 OutDir=$(OutDir) rebuild</NMakeReBuildCommandLine>
     <NMakeCleanCommandLine Condition="'$(Configuration)|$(Platform)'=='PGUpdate|x64'">cd $(ProjectDir)\..\PC
-nmake /f python3.mak MACHINE=x64 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
+"$(VSInstallDir)\VC\bin\nmake.exe" /f python3.mak MACHINE=x64 OutDir=$(OutDir) clean</NMakeCleanCommandLine>
     <NMakeOutput Condition="'$(Configuration)|$(Platform)'=='PGUpdate|x64'">$(OutDir)python3.dll</NMakeOutput>
     <NMakePreprocessorDefinitions Condition="'$(Configuration)|$(Platform)'=='PGUpdate|x64'">$(NMakePreprocessorDefinitions)</NMakePreprocessorDefinitions>
     <NMakeIncludeSearchPath Condition="'$(Configuration)|$(Platform)'=='PGUpdate|x64'">$(NMakeIncludeSearchPath)</NMakeIncludeSearchPath>