diff --git a/Misc/NEWS b/Misc/NEWS
index 4b82ccd2dc7..f0d200832a2 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -1290,6 +1290,8 @@ Tests
 Build
 -----
 
+- Issue #21277: Don't try to link _ctypes with a ffi_convenience library.
+
 - Issue #26884: Fix linking extension modules for cross builds.
   Patch by Xavier de Gaye.
 
diff --git a/setup.py b/setup.py
index 636dd09fab3..006ecdddb49 100644
--- a/setup.py
+++ b/setup.py
@@ -2007,7 +2007,7 @@ class PyBuildExt(build_ext):
                         break
         ffi_lib = None
         if ffi_inc is not None:
-            for lib_name in ('ffi_convenience', 'ffi_pic', 'ffi'):
+            for lib_name in ('ffi', 'ffi_pic'):
                 if (self.compiler.find_library_file(lib_dirs, lib_name)):
                     ffi_lib = lib_name
                     break