diff --git a/Lib/test/test_multiprocessing_main_handling.py b/Lib/test/test_multiprocessing_main_handling.py
index bfd67378a5f..97539e061ea 100644
--- a/Lib/test/test_multiprocessing_main_handling.py
+++ b/Lib/test/test_multiprocessing_main_handling.py
@@ -22,6 +22,9 @@ from test.script_helper import (
 import multiprocessing
 AVAILABLE_START_METHODS = set(multiprocessing.get_all_start_methods())
 
+# Issue #22332: Skip tests if sem_open implementation is broken.
+support.import_module('multiprocessing.synchronize')
+
 verbose = support.verbose
 
 test_source = """\