diff --git a/Lib/test/test_array.py b/Lib/test/test_array.py
index 206042f7443..4c870d72906 100755
--- a/Lib/test/test_array.py
+++ b/Lib/test/test_array.py
@@ -188,6 +188,17 @@ class BaseTest(unittest.TestCase):
                 f.close()
             test_support.unlink(test_support.TESTFN)
 
+    def test_fromfile_ioerror(self):
+        # Issue #5395: Check if fromfile raises a proper IOError
+        # instead of EOFError.
+        a = array.array(self.typecode)
+        f = open(test_support.TESTFN, 'wb')
+        try:
+            self.assertRaises(IOError, a.fromfile, f, len(self.example))
+        finally:
+            f.close()
+            test_support.unlink(test_support.TESTFN)
+
     def test_tofromlist(self):
         a = array.array(self.typecode, 2*self.example)
         b = array.array(self.typecode)
diff --git a/Misc/ACKS b/Misc/ACKS
index b6634a789b7..96523fea6c5 100644
--- a/Misc/ACKS
+++ b/Misc/ACKS
@@ -328,6 +328,7 @@ Rob Hooft
 Brian Hooper
 Randall Hopper
 Nadav Horesh
+Jan Hosang
 Ken Howard
 Brad Howes
 Chih-Hao Huang
diff --git a/Misc/NEWS b/Misc/NEWS
index c324df36976..fa9d522b618 100644
--- a/Misc/NEWS
+++ b/Misc/NEWS
@@ -81,6 +81,10 @@ C-API
 Library
 -------
 
+- Issue #5395: array.fromfile() would raise a spurious EOFError when an
+  I/O error occurred.  Now an IOError is raised instead.  Patch by chuck
+  (Jan Hosang).
+
 - Issue #1555570: email no longer inserts extra blank lines when a \r\n
   combo crosses an 8192 byte boundary.
 
diff --git a/Modules/arraymodule.c b/Modules/arraymodule.c
index b571fe8254c..da1bb02e82e 100644
--- a/Modules/arraymodule.c
+++ b/Modules/arraymodule.c
@@ -1262,8 +1262,14 @@ array_fromfile(arrayobject *self, PyObject *args)
             PyMem_RESIZE(item, char, Py_SIZE(self)*itemsize);
             self->ob_item = item;
             self->allocated = Py_SIZE(self);
-            PyErr_SetString(PyExc_EOFError,
-                             "not enough items in file");
+            if (ferror(fp)) {
+                PyErr_SetFromErrno(PyExc_IOError);
+                clearerr(fp);
+            }
+            else {
+                PyErr_SetString(PyExc_EOFError,
+                                "not enough items in file");
+            }
             return NULL;
         }
     }