diff --git a/crates/ruff/resources/test/fixtures/pyupgrade/UP022.py b/crates/ruff/resources/test/fixtures/pyupgrade/UP022.py
index c5ccb93107..e93901bde1 100644
--- a/crates/ruff/resources/test/fixtures/pyupgrade/UP022.py
+++ b/crates/ruff/resources/test/fixtures/pyupgrade/UP022.py
@@ -35,6 +35,13 @@ if output:
         encoding="utf-8",
     )
 
+output = subprocess.run(
+    ["foo"], stdout=subprocess.PIPE, capture_output=True, stderr=subprocess.PIPE
+)
+
+output = subprocess.run(
+    ["foo"], stdout=subprocess.PIPE, capture_output=False, stderr=subprocess.PIPE
+)
 
 # Examples that should NOT trigger the rule
 from foo import PIPE
diff --git a/crates/ruff/src/rules/pyupgrade/rules/replace_stdout_stderr.rs b/crates/ruff/src/rules/pyupgrade/rules/replace_stdout_stderr.rs
index 86094b21fb..11c3591144 100644
--- a/crates/ruff/src/rules/pyupgrade/rules/replace_stdout_stderr.rs
+++ b/crates/ruff/src/rules/pyupgrade/rules/replace_stdout_stderr.rs
@@ -50,29 +50,6 @@ impl AlwaysAutofixableViolation for ReplaceStdoutStderr {
     }
 }
 
-/// Generate a [`Edit`] for a `stdout` and `stderr` [`Keyword`] pair.
-fn generate_fix(
-    stdout: &Keyword,
-    stderr: &Keyword,
-    call: &ast::ExprCall,
-    source: &str,
-) -> Result<Fix> {
-    let (first, second) = if stdout.start() < stderr.start() {
-        (stdout, stderr)
-    } else {
-        (stderr, stdout)
-    };
-    Ok(Fix::suggested_edits(
-        Edit::range_replacement("capture_output=True".to_string(), first.range()),
-        [remove_argument(
-            second,
-            &call.arguments,
-            Parentheses::Preserve,
-            source,
-        )?],
-    ))
-}
-
 /// UP022
 pub(crate) fn replace_stdout_stderr(checker: &mut Checker, call: &ast::ExprCall) {
     if checker
@@ -109,3 +86,41 @@ pub(crate) fn replace_stdout_stderr(checker: &mut Checker, call: &ast::ExprCall)
         checker.diagnostics.push(diagnostic);
     }
 }
+
+/// Generate a [`Edit`] for a `stdout` and `stderr` [`Keyword`] pair.
+fn generate_fix(
+    stdout: &Keyword,
+    stderr: &Keyword,
+    call: &ast::ExprCall,
+    source: &str,
+) -> Result<Fix> {
+    let (first, second) = if stdout.start() < stderr.start() {
+        (stdout, stderr)
+    } else {
+        (stderr, stdout)
+    };
+
+    if call.arguments.find_keyword("capture_output").is_some() {
+        // Remove both arguments.
+        Ok(Fix::suggested_edits(
+            remove_argument(first, &call.arguments, Parentheses::Preserve, source)?,
+            [remove_argument(
+                second,
+                &call.arguments,
+                Parentheses::Preserve,
+                source,
+            )?],
+        ))
+    } else {
+        // Replace one argument with `capture_output=True`, and remove the other.
+        Ok(Fix::suggested_edits(
+            Edit::range_replacement("capture_output=True".to_string(), first.range()),
+            [remove_argument(
+                second,
+                &call.arguments,
+                Parentheses::Preserve,
+                source,
+            )?],
+        ))
+    }
+}
diff --git a/crates/ruff/src/rules/pyupgrade/snapshots/ruff__rules__pyupgrade__tests__UP022.py.snap b/crates/ruff/src/rules/pyupgrade/snapshots/ruff__rules__pyupgrade__tests__UP022.py.snap
index 75df54757d..2d7ed39efa 100644
--- a/crates/ruff/src/rules/pyupgrade/snapshots/ruff__rules__pyupgrade__tests__UP022.py.snap
+++ b/crates/ruff/src/rules/pyupgrade/snapshots/ruff__rules__pyupgrade__tests__UP022.py.snap
@@ -157,6 +157,8 @@ UP022.py:29:14: UP022 [*] Sending `stdout` and `stderr` to `PIPE` is deprecated,
 35 | |         encoding="utf-8",
 36 | |     )
    | |_____^ UP022
+37 |   
+38 |   output = subprocess.run(
    |
    = help: Replace with `capture_output` keyword argument
 
@@ -172,4 +174,52 @@ UP022.py:29:14: UP022 [*] Sending `stdout` and `stderr` to `PIPE` is deprecated,
 35 34 |         encoding="utf-8",
 36 35 |     )
 
+UP022.py:38:10: UP022 [*] Sending `stdout` and `stderr` to `PIPE` is deprecated, use `capture_output`
+   |
+36 |       )
+37 |   
+38 |   output = subprocess.run(
+   |  __________^
+39 | |     ["foo"], stdout=subprocess.PIPE, capture_output=True, stderr=subprocess.PIPE
+40 | | )
+   | |_^ UP022
+41 |   
+42 |   output = subprocess.run(
+   |
+   = help: Replace with `capture_output` keyword argument
+
+ℹ Suggested fix
+36 36 |     )
+37 37 | 
+38 38 | output = subprocess.run(
+39    |-    ["foo"], stdout=subprocess.PIPE, capture_output=True, stderr=subprocess.PIPE
+   39 |+    ["foo"], capture_output=True
+40 40 | )
+41 41 | 
+42 42 | output = subprocess.run(
+
+UP022.py:42:10: UP022 [*] Sending `stdout` and `stderr` to `PIPE` is deprecated, use `capture_output`
+   |
+40 |   )
+41 |   
+42 |   output = subprocess.run(
+   |  __________^
+43 | |     ["foo"], stdout=subprocess.PIPE, capture_output=False, stderr=subprocess.PIPE
+44 | | )
+   | |_^ UP022
+45 |   
+46 |   # Examples that should NOT trigger the rule
+   |
+   = help: Replace with `capture_output` keyword argument
+
+ℹ Suggested fix
+40 40 | )
+41 41 | 
+42 42 | output = subprocess.run(
+43    |-    ["foo"], stdout=subprocess.PIPE, capture_output=False, stderr=subprocess.PIPE
+   43 |+    ["foo"], capture_output=False
+44 44 | )
+45 45 | 
+46 46 | # Examples that should NOT trigger the rule
+