diff --git a/crates/ruff_linter/resources/test/fixtures/flake8_bugbear/B004.py b/crates/ruff_linter/resources/test/fixtures/flake8_bugbear/B004.py
index 83590228a6..3a81f8c28b 100644
--- a/crates/ruff_linter/resources/test/fixtures/flake8_bugbear/B004.py
+++ b/crates/ruff_linter/resources/test/fixtures/flake8_bugbear/B004.py
@@ -29,3 +29,13 @@ def this_is_fine():
     o = object()
     if callable(o):
         print("Ooh, this is actually callable.")
+
+# https://github.com/astral-sh/ruff/issues/18741
+# The autofix for this is unsafe due to the comments.
+hasattr(
+    # comment 1
+    obj,  # comment 2
+    # comment 3
+    "__call__",  # comment 4
+    # comment 5
+)
diff --git a/crates/ruff_linter/src/rules/flake8_bugbear/rules/unreliable_callable_check.rs b/crates/ruff_linter/src/rules/flake8_bugbear/rules/unreliable_callable_check.rs
index 5bfaefe079..fbeea00d97 100644
--- a/crates/ruff_linter/src/rules/flake8_bugbear/rules/unreliable_callable_check.rs
+++ b/crates/ruff_linter/src/rules/flake8_bugbear/rules/unreliable_callable_check.rs
@@ -1,3 +1,4 @@
+use ruff_diagnostics::Applicability;
 use ruff_macros::{ViolationMetadata, derive_message_formats};
 use ruff_python_ast::{self as ast, Expr};
 use ruff_text_size::Ranged;
@@ -26,6 +27,21 @@ use crate::{Edit, Fix, FixAvailability, Violation};
 /// callable(obj)
 /// ```
 ///
+/// ## Fix safety
+/// This rule's fix is marked as unsafe if there's comments in the `hasattr` call
+/// expression, as comments may be removed.
+///
+/// For example, the fix would be marked as unsafe in the following case:
+/// ```python
+/// hasattr(
+///     # comment 1
+///     obj,  # comment 2
+///     # comment 3
+///     "__call__",  # comment 4
+///     # comment 5
+/// )
+/// ```
+///
 /// ## References
 /// - [Python documentation: `callable`](https://docs.python.org/3/library/functions.html#callable)
 /// - [Python documentation: `hasattr`](https://docs.python.org/3/library/functions.html#hasattr)
@@ -84,7 +100,15 @@ pub(crate) fn unreliable_callable_check(
                 format!("{binding}({})", checker.locator().slice(obj)),
                 expr.range(),
             );
-            Ok(Fix::safe_edits(binding_edit, import_edit))
+            Ok(Fix::applicable_edits(
+                binding_edit,
+                import_edit,
+                if checker.comment_ranges().intersects(expr.range()) {
+                    Applicability::Unsafe
+                } else {
+                    Applicability::Safe
+                },
+            ))
         });
     }
 }
diff --git a/crates/ruff_linter/src/rules/flake8_bugbear/snapshots/ruff_linter__rules__flake8_bugbear__tests__B004_B004.py.snap b/crates/ruff_linter/src/rules/flake8_bugbear/snapshots/ruff_linter__rules__flake8_bugbear__tests__B004_B004.py.snap
index 2d67212e68..1ef53a053b 100644
--- a/crates/ruff_linter/src/rules/flake8_bugbear/snapshots/ruff_linter__rules__flake8_bugbear__tests__B004_B004.py.snap
+++ b/crates/ruff_linter/src/rules/flake8_bugbear/snapshots/ruff_linter__rules__flake8_bugbear__tests__B004_B004.py.snap
@@ -85,4 +85,32 @@ B004.py:24:8: B004 [*] Using `hasattr(x, "__call__")` to test if x is callable i
    25 |+    if builtins.callable(o):
 25 26 |         print("STILL a bug!")
 26 27 | 
-27 28 |
+27 28 | 
+
+B004.py:35:1: B004 [*] Using `hasattr(x, "__call__")` to test if x is callable is unreliable. Use `callable(x)` for consistent results.
+   |
+33 |   # https://github.com/astral-sh/ruff/issues/18741
+34 |   # The autofix for this is unsafe due to the comments.
+35 | / hasattr(
+36 | |     # comment 1
+37 | |     obj,  # comment 2
+38 | |     # comment 3
+39 | |     "__call__",  # comment 4
+40 | |     # comment 5
+41 | | )
+   | |_^ B004
+   |
+   = help: Replace with `callable()`
+
+ℹ Unsafe fix
+32 32 | 
+33 33 | # https://github.com/astral-sh/ruff/issues/18741
+34 34 | # The autofix for this is unsafe due to the comments.
+35    |-hasattr(
+36    |-    # comment 1
+37    |-    obj,  # comment 2
+38    |-    # comment 3
+39    |-    "__call__",  # comment 4
+40    |-    # comment 5
+41    |-)
+   35 |+callable(obj)