diff --git a/crates/uv-distribution-types/src/requires_python.rs b/crates/uv-distribution-types/src/requires_python.rs
index ae9fee7fe..786aed83a 100644
--- a/crates/uv-distribution-types/src/requires_python.rs
+++ b/crates/uv-distribution-types/src/requires_python.rs
@@ -5,10 +5,11 @@ use version_ranges::Ranges;
 use uv_distribution_filename::WheelFilename;
 use uv_pep440::{
     LowerBound, UpperBound, Version, VersionSpecifier, VersionSpecifiers,
-    release_specifiers_to_ranges,
+    release_specifier_to_range, release_specifiers_to_ranges,
 };
 use uv_pep508::{MarkerExpression, MarkerTree, MarkerValueVersion};
 use uv_platform_tags::{AbiTag, LanguageTag};
+use uv_warnings::warn_user_once;
 
 /// The `Requires-Python` requirement specifier.
 ///
@@ -66,15 +67,28 @@ impl RequiresPython {
     ) -> Option<Self> {
         // Convert to PubGrub range and perform an intersection.
         let range = specifiers
-            .into_iter()
-            .map(|specifier| release_specifiers_to_ranges(specifier.clone()))
-            .fold(None, |range: Option<Ranges<Version>>, requires_python| {
-                if let Some(range) = range {
-                    Some(range.intersection(&requires_python))
-                } else {
-                    Some(requires_python)
+            .map(|specs| {
+                // Warn if there’s exactly one `~=` specifier without a patch.
+                if let [spec] = &specs[..] {
+                    if spec.is_tilde_without_patch() {
+                        if let Some((lo_b, hi_b)) = release_specifier_to_range(spec.clone())
+                            .bounding_range()
+                            .map(|(l, u)| (l.cloned(), u.cloned()))
+                        {
+                            let lo_spec = LowerBound::new(lo_b).specifier().unwrap();
+                            let hi_spec = UpperBound::new(hi_b).specifier().unwrap();
+                            warn_user_once!(
+                                "The release specifier (`{spec}`) contains a compatible release \
+                                match without a patch version. This will be interpreted as \
+                                `{lo_spec}, {hi_spec}`. Did you mean `{spec}.0` to freeze the minor \
+                                version?"
+                            );
+                        }
+                    }
                 }
-            })?;
+                release_specifiers_to_ranges(specs.clone())
+            })
+            .reduce(|acc, r| acc.intersection(&r))?;
 
         // If the intersection is empty, return `None`.
         if range.is_empty() {
diff --git a/crates/uv-pep440/src/version_ranges.rs b/crates/uv-pep440/src/version_ranges.rs
index 2bd7dcd4d..26cd048d3 100644
--- a/crates/uv-pep440/src/version_ranges.rs
+++ b/crates/uv-pep440/src/version_ranges.rs
@@ -130,11 +130,10 @@ impl From<VersionSpecifier> for Ranges<Version> {
 ///
 /// See: <https://github.com/pypa/pip/blob/a432c7f4170b9ef798a15f035f5dfdb4cc939f35/src/pip/_internal/resolution/resolvelib/candidates.py#L540>
 pub fn release_specifiers_to_ranges(specifiers: VersionSpecifiers) -> Ranges<Version> {
-    let mut range = Ranges::full();
-    for specifier in specifiers {
-        range = range.intersection(&release_specifier_to_range(specifier));
-    }
-    range
+    specifiers
+        .into_iter()
+        .map(release_specifier_to_range)
+        .fold(Ranges::full(), |acc, range| acc.intersection(&range))
 }
 
 /// Convert the [`VersionSpecifier`] to a PubGrub-compatible version range, using release-only
diff --git a/crates/uv-pep440/src/version_specifier.rs b/crates/uv-pep440/src/version_specifier.rs
index 4255c13fa..19acff2eb 100644
--- a/crates/uv-pep440/src/version_specifier.rs
+++ b/crates/uv-pep440/src/version_specifier.rs
@@ -416,7 +416,7 @@ impl VersionSpecifier {
         &self.operator
     }
 
-    /// Get the version, e.g. `<=` in `<= 2.0.0`
+    /// Get the version, e.g. `2.0.0` in `<= 2.0.0`
     pub fn version(&self) -> &Version {
         &self.version
     }
@@ -615,6 +615,11 @@ impl VersionSpecifier {
             | Operator::NotEqual => false,
         }
     }
+
+    /// Returns true if this is a `~=` specifier without a patch version (e.g. `~=3.11`).
+    pub fn is_tilde_without_patch(&self) -> bool {
+        self.operator == Operator::TildeEqual && self.version.release().len() == 2
+    }
 }
 
 impl FromStr for VersionSpecifier {
diff --git a/crates/uv/tests/it/lock.rs b/crates/uv/tests/it/lock.rs
index b1d6c5327..5fb0fcd27 100644
--- a/crates/uv/tests/it/lock.rs
+++ b/crates/uv/tests/it/lock.rs
@@ -4535,6 +4535,70 @@ fn lock_requires_python_exact() -> Result<()> {
     Ok(())
 }
 
+/// Lock a requirement from PyPI with a compatible release Python bound.
+#[cfg(feature = "python-patch")]
+#[test]
+fn lock_requires_python_compatible_specifier() -> Result<()> {
+    let context = TestContext::new("3.13.0");
+
+    let pyproject_toml = context.temp_dir.child("pyproject.toml");
+    pyproject_toml.write_str(
+        r#"
+        [project]
+        name = "warehouse"
+        version = "1.0.0"
+        requires-python = "~=3.13"
+        "#,
+    )?;
+
+    uv_snapshot!(context.filters(), context.lock(), @r###"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+
+    ----- stderr -----
+    warning: The release specifier (`~=3.13`) contains a compatible release match without a patch version. This will be interpreted as `>=3.13, <4`. Did you mean `~=3.13.0` to freeze the minor version?
+    Resolved 1 package in [TIME]
+    "###);
+
+    pyproject_toml.write_str(
+        r#"
+        [project]
+        name = "warehouse"
+        version = "1.0.0"
+        requires-python = "~=3.13, <3.14"
+        "#,
+    )?;
+
+    uv_snapshot!(context.filters(), context.lock(), @r"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    ");
+
+    pyproject_toml.write_str(
+        r#"
+        [project]
+        name = "warehouse"
+        version = "1.0.0"
+        requires-python = "~=3.13.0"
+        "#,
+    )?;
+
+    uv_snapshot!(context.filters(), context.lock(), @r"
+    success: true
+    exit_code: 0
+    ----- stdout -----
+
+    ----- stderr -----
+    Resolved 1 package in [TIME]
+    ");
+    Ok(())
+}
+
 /// Fork, even with a single dependency, if the minimum Python version is increased.
 #[test]
 fn lock_requires_python_fork() -> Result<()> {